The safety of bio-identical hormones is a very controversial topic. As discussed in the previous question, any change in the chemical structure of hormones or other chemical messengers in our bodies will also change the function and metabolism of that particular messenger. That change in structure profoundly effects how our body will respond to that messenger which is often a negative response because our body is suddenly forced to deal with a chemical agent that it was not designed to recognize. There are many inherent problems when this occurs. That is why we use only hormones that are bio-identical to our body body’s own hormones. There are many other factors that enter into the safety and efficacy of hormone replacement: route of administration (oral, injection and skin), nutritional status, pre-existing medical conditions, age of the individual. For example a nutritional deficiency such as vitamin B12 deficiency can profoundly effect the action and metabolism of your hormones.

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